Mannose: what it is and how it works against Cystitis

D-mannose is a natural remedy used for the treatment and prevention of Cystitis, both acute and chronic.

The treatment protocols specific to each type of Cystitis, developed by Cistite.info, can help you fight and prevent Cystitis.

Discover Puroman pure D-mannose and all the other products partnered with Cistite.info to tackle cystitis and prevent recurrences!

• What is D-mannose
• How D-mannose works
• Buy D-mannose

D-mannose

What is D-mannose?

D-mannose is a simple sugar, that is, a monosaccharide—meaning a sugar made up of a single molecule (like glucose, fructose, galactose, and galabose). Once absorbed (that is, once it passes from the intestine into the bloodstream), it is not converted into glycogen and therefore is not stored in the liver or other organs, nor is it used by the body. Instead, it is eliminated through the kidneys, reaching high concentrations in the urinary tract, where it exerts its anti-adhesive effects on the bacteria present there.
D-mannose in fact has a high affinity for mannose-sensitive “legs” (called lectins, fimbriae, or pili) found on many bacteria, particularly Escherichia coli.

Bacteria, in order to trigger Cystitis (that is, bladder inflammation), must attach to the bladder walls through lectins. This condition is essential for Cystitis to develop. If bacteria do not adhere to the bladder walls, there will be no inflammation, no pain, and no Cystitis, but simply bacteriuria, meaning the presence of harmless bacteria in the urine. Bacteriuria does not need to be treated, except in particular conditions such as pregnancy and the presence of kidney disease.

D-mannose, since it has very few and insignificant side effects, can also be taken by people with diabetes, by newborns, children, and by women who are pregnant or breastfeeding.

This regimen will help you take D-mannose correctly, both to treat an acute episode of Cystitis and to prevent its onset.

Get the D-mannose dosing regimen for free

Hoe does D-mannose work?

D-mannose, by attaching itself to the “legs” of bacteria, prevents them from adhering to the urinary mucosa. To give an example, we can compare bacterial lectins to the hooked side of Velcro and the bladder to the soft, fuzzy side. The adhesion between the two is very strong. Mannose has the same “soft surface” as the bladder and is able to bind to bacteria before they attach elsewhere.
Once bound to D-mannose, bacteria can no longer adhere to the bladder and remain floating in the urine, from which they are eliminated through urination. The adhesive capacity of bacteria toward mannose is greater than their adhesion to the bladder; therefore, D-mannose is also able to detach bacteria that are already anchored to the mucosa and to attract those that have penetrated more deeply.
For this reason, during the initial periods of mannose intake it is common, even in the absence of symptoms, to find positive urine cultures (and sometimes with bacterial counts even higher than usual): this is because the bacteria detected are those being eliminated from the bladder, and the absence of symptoms shows that this is harmless bacteriuria and not Cystitis.

It has been observed that in the urine of many women suffering from chronic Cystitis, the Tamm–Horsfall glycoprotein is absent or present in low amounts. This protein is produced by the kidneys and released into the urine. It binds to mannose-sensitive lectins (type 1) on bacteria, preventing them from adhering to the bladder walls.
Some studies have shown that mice lacking Tamm–Horsfall glycoprotein were much more susceptible to urinary infections caused by bacteria equipped with type 1 lectins, compared with mice that had normal amounts of this protein in their urine. The Tamm–Horsfall protein is rich in D-mannose.

IgA as well (antibodies present in human secretions and therefore in urine, saliva, vaginal fluids, etc.), like the Tamm–Horsfall protein, inhibit the ability of bacteria to adhere via type 1 lectins.

A deficiency of Tamm–Horsfall glycoproteins or IgA can therefore be compensated for by taking D-mannose.

It has been shown that D-mannose binds not only to bacteria, but also to the toxins they produce to damage the GAG layer and reach the deeper mucosal layer where they then take hold.

“D-mannose, in this way, facilitates the detachment of bacteria and their subsequent elimination with the normal urinary flow. For these reasons, D-mannose has become the winning cornerstone in the treatment of cystitis.”
Taken from "D-Mannosio: finalmente uno zucchero che fa bene, senza effetti collaterali" written by Dr. Emanuela Mistrangelo

In-depth look: D-mannose dosage and intake regimen

Which D-mannose should you buy and where can you buy it?

There are various brands of products containing D-mannose available on the market (Deakos, Urogyn, Melura, Delturil, Ausilium, Legnani, Waterfall, Long Life, Dimann, Cystoman, Mannocist, etc.).

Our association Cistite.info APS is the main reference point in Italy for those who wish to address uro-genital disorders in a natural way. Through targeted programs and specialized professionals, it offers specific courses and activities to regain balance and relief. In collaboration with doctors and pharmacists, it commissioned the production of Puroman from the Ti-Lab laboratory, the laboratory of the renowned Farmacia Tili in Erba (Como). Puroman is ultra-pure D-mannose, highly water-soluble, free from heavy metals, excipients, sweeteners, and preservatives, and ideal for daily use even at high doses. Thanks to direct sales from producer to consumer, we have been able to guarantee our members D-mannose of the highest quality at a highly competitive price. Moreover, direct sales allow Ti-Lab to package Puroman in small batches whenever needed, ensuring that the consumer always receives a very fresh product, never more than one month old at the time of delivery.

A 20% discount on purchases is available for our members. By becoming a member, you will be able to access numerous benefits, free consultations, and initiatives designed especially for you.

Bibliography

1. Tamm-Horsfall protein: a multilayered defence molecule against urinary tract infection. Säemann MD, Weichhart T, Hörl WH, Zlabinger GJ, Medical University of Vienna, Vienna, Austria.
2. Effect of D-mannose and D-glucose on Escherichia coli bacteriuria in rats, Michaels E, Chmiel J, Plotkin B, Schaeffer A., Urol Res. 1983;11:97-102